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Phosphoinositides play a central role in the regulation of numerous cell signaling processes. Their invovlement in cytoskeletal remodeling, vesicle trafficking, cell survival, mitogenesis, DNA repair, transcription regulation, exo-endocytosis, ion channel modulation, phagocytosis, and apoptosis have been reported.
Phosphoinositides are a form of lipids that have two fatty acid chains that insert into the membrane, and a water-soluble inositol ring head group that sticks out of the membrane into the cell. This inositol ring can be quickly modified via phosphorylation or dephosphorylation. This phosphorylation-dephosphorylation of phosphoinositides represents a mechanism for regulation signaling complexes and for the regulation of membrane proteins. The inositol ring can be phosphorylated at numerous positions and each of the resulting molecules can be recognized by specific proteins, enabling swift and accurate communication in the cell.
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